Clinical Oncology Letters
https://clinicaloncologyletters.com/article/5c6ffa4a0e8825f6358e6fd5
Clinical Oncology Letters
Artigo Original

Resposta patológica completa ao tratamento neoadjuvante como fator prognóstico para pacientes com câncer de reto

Pathologic complete response to neoadjuvant treatment as a prognostic factor for patients with rectal cancer

Fernanda Borges Silva Ferreira, Claudia Vaz de Melo Sette, Damila Cristina Trufelli, Felipe José, Silva Melo Cruz, Auro del Giglio

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Resumo

Objetivo: Analisar a presença de resposta patológica completa (RPC) como fator prognóstico para sobrevida global (SG) e sobrevida livre de progressão (SLP) e avaliar se há algum fator preditivo para RCP após realização de tratamento neoadjuvante em pacientes com câncer de reto localmente avançado. Métodos: Estudo retrospectivo de pacientes admitidos no hospital Mário Covas no período de 01/01/2009 a 01/04/2014, com diagnóstico de câncer de reto localmente avançado. Foram coletados dados demográficos, clínicos e patológicos dos prontuários dos pacientes incluídos. As informações obtidas foram submetidas à análise estatística. Resultados: Foram incluídos 91 pacientes. Verificou-se melhor prognóstico, com aumento de SLP em pacientes com RCP após neoadjuvância, e linfonodos negativos no estadiamento patológico. Não houve associação entre essas características e aumento de SG. Nenhuma variável mostrou ser fator preditivo de RPC. Conclusão: A casuística apresentada demonstrou que RCP pós-tratamento neoadjuvante para câncer de reto localmente avançado é fator prognóstico em relação a SLP.

Palavras-chave

Neoplasia de reto, tratamento neoadjuvante, quimiorradioterapia, valor preditivo, prognóstico.

Abstract

Objective: The role of pathological complete response (Pcr) as a prognostic factor for overall survival (OS) and progression-free survival (PFS) and evaluate if there is any predictor of pathologic complete response after neoadjuvant treatment completion in patients with locally advanced rectal cancer. Methods: Retrospective study of patients admitted in the hospital Mario Covas from 01/01/2009 to 04/01/2014, diagnosed with locally advanced rectal cancer. We collected demographic, clinical and pathological data of medical records of patients included. The information obtained was submitted to statistical analysis. Results: During the study period 91 patientswas included and PCR after neoadjuvant therapy and negative lymph nodes during the pathological staging was associated with better PFS. There was no association between these characteristics and increased in OS. No variable was found to be predictive of PCR. Conclusion: The series presented demonstrated that complete post-neoadjuvant pathological response for locally advanced rectal cancer is a prognostic factor for progression-free survival (PFS).

Keywords

Rectal cancer, neoadjuvant treatment, predictive value, chemoradiotherapy, prognosis.

Referências

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